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Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy

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(2021) 118:e2100939118

Immunohistochemical staining for MMP13, ADAMTS5, and Collagen II in the articular cartilage showed that metformin treatment significantly reduced the MIA-induced upregulation of MMP13 and ADAMTS5, while increasing Collagen II synthesis in the articular chondrocytes (Fig